Endocrine Abstracts

Objective: Radiotherapy (RT) can achieve tumour control rates of over 90% in pituitary adenomas. The commonest toxicity of irradiation is hypopituitarism. The exact incidence is variable and requires long-term testing for deficiency of all hypothalamic-pituitary axes (HPA). The aim of this study is to determine the time to onset of individual hormonal deficiencies and establish a timeframe for endocrine testing post-RT.Methods: We retrospectively assesse...

Introduction: Radiation-induced hypopituitarism has been well-described in childhood-onset brain tumour survivors, however in adults has received less attention. The aim of this study was to assess the pituitary-related outcomes following cXRT in adults with extra-sellar gliomas.Methods: We retrospectively collected longitudinal data regarding pituitary-related outcomes from medical records of 59 patients, diagnosed with extra-sellar gliomas in adulthood...

Background: Diabetic gastroparesis is a disabling condition with no consistently effective treatment. Ghrelin infusion, in animal studies, increases gastric emptying and reverses post-operative ileus. We present the results of the first double-blind placebo-controlled cross-over study of ghrelin in gastric emptying in patients with diabetic gastroparesis....

BackgroundDiabetic gastroparesis is a disabling condition with no consistently effective treatment. Ghrelin infusion, in animal studies, increases gastric emptying and reverses post-operative ileus. We present the results of the first double-blind placebo-controlled cross-over study of ghrelin in gastric emptying in patients with diabetic gastroparesis.MethodsTen insulin requiring diabetic patients (5 men, 6 ...